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These repetitive sequences undergo mutations that add or subtract repeat units, and they are therefore highly polymorphic.
In addition to acquiring mutations that change antigenic sites on HA, influenza viruses acquire mutations that add or remove glycosylation sites on HA.
Mutations that add or change function?
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The mutant does not have the A120L mutation that adds stability to the P3Shift mutant.
Mutations in multiple glycosyltransferases that add carbohydrates to dystroglycan can cause a group of diseases that are characterized by a progressive loss of muscle function, known as congenital muscular dystrophies.
Nevertheless, a number of laboratories have demonstrated that the lysosomes of I-cell disease (ICD) fibroblasts, resulting from a mutation in the phosphotransferase that adds mannose-6-phosphate to hydrolases, have near normal levels of some lysosomal hydrolases, in addition, to the sphingolipid activator proteins prosaposin and GM2AP (16).
We demonstrated that adding a second mutation (through genetic deletion of PTEN) to these lesions was sufficient to progress it to frank carcinoma.
We have also added suggestions for mutations that may enhance the stability of these asymmetric dimers and potentially facilitate their crystallization.
In this experiment, the added cells carried a previously sequenced mutation that had been added to the genome of the tester strain with no selection for growth on lactose.
We analyzed the retinas of the knock-in Ter349Glu RHO mice, which carry a human rhodopsin gene with a read-through mutation that was generated by adding 51 amino acids to the 1D4 epitope.
The figure is consistent with the notion that Component 2 is ancestral to 4, with Component 2 acquiring a mutation at 5q21 (site of APC/MCC) and Component 4 inheriting that mutation but adding an additional one at 17q21.
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