Sentence examples for mutations specifically in from inspiring English sources

In addition, we sequenced to 188-fold depth one other ER-positive tumor with a distinctive mutator phenotype, consisting of C>A, C>G and C>T mutations specifically in a TpC context.

Because the above four mutants were selected from leucine analog resistant library by HPLC assay based on 3H4MV fraction, they might have other mutations specifically in the 3H4MV biosynthesis-related genes.

To fill this gap, we have developed a new method (MutaCYP) dedicated to the prediction of deleterious effects of missense mutations specifically in CYPs.

Nearly all the isolated clones showed single point mutations specifically in the -35 or -10 regions, indicating that the native PeSL expression level was probably so strong as to be deleterious.

Due to the conspicuous metabolic function of CS and the appearance of the later gltA mutations specifically in Cit+ isolates, it was previously hypothesized that these mutations refined the Cit+ phenotype (Blount et al., 2012).

In a study by Tory et al., it was shown that the R229Q variant only leads to a SRNS/FSGS phenotype when associated with certain NPHS2 mutations, specifically in exons 7 and 8 of the gene causing substitutions in C-terminal podocin [ 9].

They performed DNA sequencing and found that five lines had cells with a cancer-causing mutation, specifically in the TP53 gene.

In support of this model, we show that deleting the translesion polymerase REV1 lowers the mutation specifically in late-replicating/high mutation rate regions.

Another transgenic zebrafish that is used to study hepatic steatosis was generated by expressing a dominant-negative Fgf receptor mutation specifically in hepatocytes (lfabp:dnfgfr1-egfp) (Tsai et al., 2013).

In agreement with this finding, the level of c-Myc in HSCs from mice heterozygous for this Fbxw7 mutation specifically in the haematopoietic system was greater than that in control HSCs but was still lower than that in Fbxw7-deficient HSCs.

Signature amino acid mutations, specifically those in hemagglutinin (HA) and the polymerase complex that are linked to adaptation to the mammalian host and to viral replication efficiency, have been attributed to various pathogenicity profiles of H7N9 influenza viruses.