Sentence examples for mutations particularly in from inspiring English sources

It is therefore postulated that further mutations, particularly in genes crucial to the cell cycle checkpoints, must also be mutated to allow the continued proliferation and survival of these defective cells.

Cell division tended to cause DNA mutations, particularly in in vitro cell culture.

The interplay between impaired protein biosynthesis and/or function caused by missense mutations, particularly in relation to specific protein regions, has been poorly investigated.

On the other hand, HH may be present in subjects negative to HFE gene mutations, particularly in geographic area different from northern Europe [ 20].

As a consequence, this may also lead to the identification of novel mutations, particularly in geographical populations who haven't previously been able to access testing.

This study of post-transplant BCC provides the first indication that azathioprine exposure may be associated with PTCH mutations, particularly in tumours from non-sun-exposed skin.

The findings are also suggestive of screening HBV precore G1896A mutation particularly in HBeAg negative cases.

KRAS2 mutation, particularly in the 12th codon, makes cancer cell proliferation through the Ras-Raf-MEK pathway independent of EGFR activity.

Bax mutation is common in tumours, because (a) the Bax gene contains a G8 mononucleotide track and hence is prone to mutation, particularly in cells defective in mismatch repair, and (b) the inactivation of Bax confers on the cells a survival advantage and promotes tumour progression (Ionov et al, 2000).

GISTs with KIT mutation, particularly in exon 11, show a clearly better response to imatinib therapy as compared to tumours with no mutation, suggesting that detection of gain-of-function mutation and not solely KIT expression should be a requirement for the treatment (Heinrich et al, 2003).

Although 40% of stationary E. coli are reported to carry two chromosomes 57, and only ∼10−3 of Salmonella to carry a spontaneous duplication 9, the source of the repair partner in starving haploid bacteria has not been determined, and the duplication model might predominate under the specific starvation conditions that promote DSB-dependent stress-induced mutation, particularly in the chromosome.