Sentence examples for mutations especially in from inspiring English sources

For example, the APOBEC genes encode DNA cytidine deaminases that, when upregulated, promote C > G and C > T mutations especially in the T C(A|T) context (mutated base in bold; Figure  4a, Table  1) [ 41, 42, 67].

However, significant attention has been placed on off-target mutations especially in the context of human embryos.

Many of the women undergoing this procedure have inherited genetic mutations, especially in the genes BRCA1 or BRCA2.

This highly correlates with p53 mutations, especially in the DNA-binding domain [1].

Together with our report on the saeS mutation in the ausA mutant, these examples clearly show that great care should be taken during genetic manipulation of S. aureus in order to prevent acquisition of secondary mutations, especially in saeRS and agr, and appropriate genetic complementation experiments used.

Activating mutations in the BRAF gene are found at high frequency in various human cancers, and BRAFV600E is the most common of these activating mutations, especially in papillary thyroid cancer, where it is found at a frequency of 40 70% [1], [2], [3].

Without a controlled vocabulary or a clear definition of what constitutes an activating mutation, especially in the case of mutations with multiple known phenotypes, systematic identification will continue to be a challenge.

As the virus appeared in its most virulent form in 2006, it is expected that any significant mutation, especially in the multibasic aa sequence, should lead to lower virulence.

For example, the behavioral effect of any given mutation, especially in a gene that could be involved in a complex disorder, could depend on the age and genetic background of the organism.

Although L110P may be a frequent mutation, especially in Japanese patients, there were no marked differences in the clinical picture between L110P/E148Q and E148Q alone.

The second issue when using these agents is that they paradoxically activate the MAPK pathway in cells devoid of BRAF mutation, especially in the presence of an additional somatic event occurring in this pathway, such as a RAS mutation.