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Of over 100 TS mutations represented by Neurospora strains at the Fungal Genetics Stock Center, 56 are non-remedial TS lethal and 13 are TS morphological mutations.

Class II mutations (represented by specific fusion genes in the original model) impair haematopoietic differentiation and subsequent apoptosis.

In addition, we compared the performance of our models with the performance of their standard decision tree-based counterparts with mutations represented by one-letter aa codes.

Both deleterious and beneficial mutations occur in each subpopulation with fractions for beneficial and deleterious mutations represented by p b and p d (i.e. 1- p b), respectively.

Mutation datasets and presentation are as in Figure 1B but with transition mutations represented by yellow dots and transversions by blue dots.

In the simplest model, we consider diploid individuals whose genotype is represented by two chromosome types: L and R. Chromosomes R can contain deleterious mutations (represented by R d ), and only chromosomes L can have the sex-determining chromosome Y (represented by L y ).

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The ratio of deletion to point mutation (represented by the slope) was estimated using maximum likelihood (see Materials and Methods).

126 More than 90% of TP53 mutations reported in breast cancer are located in conservative regions within exons 5 to 8. 127, 127 More than 2% of all TP53 mutations are represented by three TP53 hot spot mutations, ie, 273 (CGT > CAT), 158 (CGC > CTC), and 248 (CGG > CAG).

Moreover, interactions between specific single drugs and single mutations or pairs of drugs and single mutations are represented by additional covariates.

The sum of weights a k associated with each tree sums to 1, including the random mutations tree, a noisy tree associated with random mutations and represented by a star (all atoms belong to the first level and have a distance of one to the root node).

Until now, more than 40 different subsets of mutations have been identified and about 90% of NPM1 mutations are represented by subtype A and B (78% versus 12%, respectively).

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