Therefore, these mutational data support the hypothesis that the mutations induced by comfrey in rat liver are due to PAs in the comfrey.
Specific mutations induced by triplex-forming oligonucleotides in mice.
Mutations induced by bacteriophage lambda in Escherichia coli K12.
Miyazaki, K. et al. Flower pigment mutations induced by heavy ion beam irradiation in an inter specific hybrid of Torenia.
It also implies that polymorphic sites in genomes are potential "hotspots" for mutations induced by the space environment.
Here, we show that HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV and MMS, respectively.
They also speculate that the types of mutations induced by arsenic are large chromosomal losses that are hard to detect with conventional mutation assays.
They also showed an increase in the level of mutations induced by the alkylating agent, methynitrosourea (MNU).
We further analyzed and confirmed the modified target sites by DNA sequencing and found that the mutations mainly included deletions, insertions, nucleotide transition and transversion (Fig. 3). Figure 3: DNA sequences of FVII gene mutations induced by RGNs in mice.
Our results indicate that comfrey is mutagenic in rat liver and the types of mutations induced by comfrey suggest that its tumorigenicity results from the genotoxicity of pyrrolizidine alkaloids in the plant.
Using high-throughput DNA sequencing, we also detected new mutations induced by γ-rays and UV.
