Sentence examples for mutations or abnormal from inspiring English sources

Modification of the signaling-networks via mutations or abnormal protein expression underlies the cause or consequence of many diseases including cancer.

Mutations or abnormal expression of MBD3 could therefore play a role in tumorigenesis via inappropriate regulation of other gene expression.

Several hypotheses have been put forward on the basis of molecular studies that led to the identification of many mutations or abnormal mRNA/protein expression patterns (5– 8).

Accumulation of aberrant genetic mutations or abnormal epigenetic profiles could lead to tumor initiation in adult stem cell lineages [ 12- 14].

Mutations or abnormal expression of CDKN2A/2B, EVI-1, RB, MYC and p53 among others have been reported in CML (reviewed in Radich [ 3]).

It will be interesting to see if mutations or abnormal methylation of the CTCF DS or AD sites causes defective IGF2-H19 expressinn in these individuals.

In fact, the CFTR-dependent sAC-activated cAMP pathway may be an important loop in the FSH-regulated cAMP cascade for spermatogenesis since mutation or abnormal expression of CFTR could result in impaired spermatogenesis or azoospermia.

Mutation or abnormal expression of micro-RNAs (miRNAs), which can function as either tumor suppressors or oncogenes, is implicated in various cancers (1– 4).

Genetically, the generation of the double-positive cells and dysmorphic glial cells may accompany with gene mutation or abnormal activation of some signal pathways, leading to aberrant reprogramming procedure of GSCs, compared with normal differentiation of NSCs.

Although aberrant splicing has been shown to be a consequence of mutations or the abnormal expression of splicing factors (trans-effect changes) or mutations in the splicing sequences (cis-effect mutations), the connections between aberrant splicing and cancer initiation or progression are still not well understood.

After age 35, breast tissue is more likely to have accumulated cells carrying cancer-causing mutations, or clusters of abnormal cells with the potential to become cancerous: however, it was not known how these cells were affected by a late-age first pregnancy.