Sentence examples for mutations or environmental from inspiring English sources

Genetic factors may predispose patients to develop PD if combined with other gene mutations or environmental toxins.

Alterations of this sequence by mutations or environmental insults leads to the formation of misconnected circuits endowed with a 'pre-symptomatic signature'.

Lewis Cantley, director of the Cancer Center at Beth Israel Deaconess Medical Center at Harvard Medical School, says that up to 80percentt of all human cancers are driven by either mutations or environmental factors that work to enhance or mimic the effect of insulin on the incipient tumor cells.

Robustness or canalization refers to the invariance of the phenotype in spite of genetic mutations or environmental perturbations.

Moreover, mutations or environmental changes can place an individual closer to the edge of the homeostatic region, thus predisposing that individual to deleterious effects caused by additional mutations or environmental changes.

The challenge will be to decipher which of the hundreds of candidate second site mutations or environmental factors may be responsible for the buffering against disease.

The accumulation of mutations, aneuploidies, or epigenetic changes frequently exceeds the normal rate of such events due to a predisposing mutation or environmental state that increases genetic instability.

First, because of some chance preadaptation, mutation or environmental change, organisms find themselves favoured in their new environment (Sakai et al. 2001).

The distinction is that the compensatory functions are not activated until the cell has been rewired by a genetic mutation or environmental perturbation such as drug treatment.

Thus, cellular systems maintain homeostasis partly by ensuring that processes do not depend on any single component, which could easily be perturbed by mutation or environmental effects, setting the scene for synthetic lethal interactions [4,11,13].

Interestingly, both genetic mutations (familiar) or environmental insults (sporadic) can trigger protein aggregation diseases, implying that a common mechanism may exist to link these clinically distinct diseases.