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However, when examining other cancer types it remains to be determined whether other mutations might occur.
How many mutations might occur in the normal breast epithelial stem cell in a 10-year period?
Second, above the change point, deletion and insertion mutations might occur back and forth within a population at an increasing rate.
Such advantageous mutations might occur either in one of the multiple loci coding for MHC class I molecules, or in one of the genes encoding proteins involved in the antigen presentation/recognition pathway (PRIAP).
The aim of this study was to sequence the entire critical EGFR tyrosine kinase domain and to determine how frequently drug-sensitising and drug-resistant EGFR mutations might occur in a large cohort of SGCs of the main histopathological types.
Though the sample size prevents statistical considerations, MYD88 mutations might occur even before 13q14 deletion (one of six patients), indicating that activation of the Toll-like receptor pathway could be important in the initiation of a fraction of CLL tumors (Arvaniti et al., 2011).
Similar(52)
However, we considered that gene mutation might occur at the STR loci excluded.
As the WTX-gene harbors a short T6-microsatellite in its N-terminal coding region, we hypothesized that frameshift-mutations might occur in MSI-H CRCs in the WTX gene, thus additionally contributing to the stabilization of β-CATENIN in human CRCs.
These data suggest that the AKT1 mutation might occur in a tissue-specific manner and is more associated with the tumour types with frequent PIK3CA alterations.
Our initial conception of genes had been that of strands of integrated DNA code in which a point mutation might occur and from which different biological expressions might directly devolve.
Such a mechanism could account for overexpression of MT in Barrett's oesophagus while loss of this gain mutation might occur in those lines of cells that become cancer.
Related(20)
adjustments might occur
mutations might appear
mutations might emerge
breakthroughs might occur
variants might occur
developments might occur
mutations might arise
mutations might exist
transfer might occur
mutations might build
mutations might vary
mutations might result
mutations might link
mutations might have
mutations might drive
mutations might alter
mutations might affect
mutations might impair
mutations might cause
mutations might suppress
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