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When CGI harbors TSS and becomes a dominate regulator of gene transcription, the mutational forces that induce mutations might have deleterious impact.
Other seemingly innocuous mutations might have led evolution down another path.
Second, the environment in which people find themselves has also changed rapidly, creating new contexts in which those mutations might have beneficial effects.That environmental change itself has two causes.
All of these mutations might have substantial impact on phosphorylation and gating properties of the channel.
In 1994, UCLA scientist Jared Diamond promoted a similar but more simplistic version of this theory, writing that the operant mutations might have been positively selected "in Jews for the intelligence putatively required to survive recurrent persecution, and also to make a living by commerce, because Jews were barred from the agricultural jobs available to the non-Jewish people".
Therefore, the accumulated compensatory mutations might have masked the true protective effect of B*57/*5801.
Since reverse transcription is the first step for HIV replication after viral entry into host cells, our results suggested that the two mutations might have affected the RT activity.
Similar(4)
Overall, the average heritability of all expression traits was 0.0005; considering only the 3385 traits with nonzero estimates of among-line variance in model (1) (i.e., the traits for which there is some evidence that a mutation might have occurred), the average mutational heritability was 0.0018.
While it seems counterintuitive that a mutation that is so common would be related to preventing the reproduction of a species, Dr. Bevins said the mutation might have survived because it has another function, still unknown but useful.
A late mutation might have no effect at all (and therefore would not be selected), whereas if the same mutation had happened early, natural selection would have picked it up and spread it through the population at great speed.Dr Wichman's work implies that trying to think several steps ahead of any virus will not be a simple task.
The authors suggest that the mutation might have had an adaptive advantage for modern humans, who migrated out of Africa into Europe and Asia beginning about 60,000 years ago.
More suggestions(15)
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mutations might vary
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mutations might link
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mutations might suppress
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Justyna Jupowicz-Kozak
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