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These mutations might vary between tumours, which might be one of the mechanisms responsible for differences in response to treatment and resistance to treatment.
In particular, the clinical consequences of PIK3CA mutations might vary according to the status of well-known molecular markers in breast cancer, namely ERα, progesterone receptor (PR), and ERBB2.
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These contrasting effects of this resistant parasite haplotype suggest that effects of the A581 G mutation might vary among populations.
At present, there is insufficient data to know whether mutation rates might vary sharply within Plantago mitochondrial genomes.
Variation in genome-wide patterns of SNP types in two other C. elegans natural isolates (CB4856, CB4858) suggest that base-substitution mutation processes might vary between these two strains (Solorzano et al. 2011), though selective differences on base substitution processes between the strains might also be responsible for the different SNP patterns between the strains.
slc mutations might alter mitotic chromosome condensation.
Nevertheless, owing to tumour-specific activating and deactivating mutations, the efficacy of TP inhibitors might vary not only between individual tumours but also between different types of tumours.
The effects of some established lifestyle factors might vary in relation to family history [ 10] or BRCA1 or BRCA2 mutation status [ 11].
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