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Helfand speculates that Indy mutations might alter metabolism in a manner similar to caloric restriction, which extends life-span in mammals and other animals.
It should be noted that such mutations might alter some unknown, yet uncharacterized, functional properties of STIM-2.
Our results suggest that the R632W and R747W mutations might alter PLA2G6 function by increasing the catalytic rate for PC.
To further examine this effect, we also tested if dFKBP59 mutations might alter the lifespan of Aβ42-expressing flies.
slc mutations might alter mitotic chromosome condensation.
In addition, the unique biological responses of the embryonic heart to sarcomeric gene mutations might alter the final pathological characteristics of the adult disease.
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Another possible mechanism for the elevated incidence and severity of lesions in the CF mouse is that the ΔF508 mutation might alter the composition of the tooth enamel.
We hypothesized that such a mutation might alter MAVS conformation, thus modifying its interaction with downstream signalling molecules.
For putative mutations in nine genes predicted from network analysis (Table 1), we first analyze if the mutation might alter substrate binding, catalytic activity, or structural stability.
The Y201H mutation might alter the levels of lysine in the human body, and may favour the interaction between PLG and lysine, instead of with PrPsc.
By contrast, the L89 side chain is predicted to be in the Mre11 hydrophobic core, although modelling suggested that the mre11-L89V mightion might alter the stability of the α-helix containing Q70.
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