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Exact(6)
From these crosses we find the ratio of non-synonymous to synonymous mutations is lower in duplicated genes, which suggests that they are under greater purifying selection.
It is clear from our study that the sensitivity to EndoA-BAR mutations is lower in larvae than in adults.
In Brazil, the prevalence of HFE mutations is lower than in populations of northern Europe.
The percentage of single heterozygous mutations is lower than suggested by in vivo analysis, and thus, the importance of the DNE of TP53 mutations is undermined.
Transcription factor mutations in the HNF1A or HNF4A genes cause a similar progressive diabetic phenotype although the penetrance of HNF4A mutations is lower (S. Ellard and A. T. Hattersley, unpublished data).
Since the probability of increasing the average fitness by random mutations is lower under frequency-dependent selection (see Figure 1), we must conclude that asexual populations face an even bigger challenge to maintain their average fitnesses under frequency dependent selection than under constant selection in a finite population.
Similar(54)
Furthermore, the probability of new mutations is lowered, resulting in better viral suppression for a longer duration.
The results confirmed that the fitness consequences of the accumulated mutations were lower in the viruses historically evolving at low coinfection, meaning that these viruses were indeed more robust.
The number of stop mutations was lower than the CODDLE predicted proportions.
Overall, substitution scores of Mendelian disease and cancer somatic mutations are lower than those of polymorphic variants, suggesting deleterious and harmful effects when they occur.
As expected, the distribution of mutations reflected patterns previously observed in human tumors, although the frequency of TS mutations was lower (reflective of the reduced coverage of such mutations by OncoMap).
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