Exact(3)
In addition, the level of GLR-1 in the cell bodies of ire-1 mutants is lower than that in wild-type cell bodies, suggesting that much of the ER-trapped receptor in ire-1 mutants is removed by ERAD [74], [75].
The relative fitness of the resistant mutants is lower in the second scenario compared to the first one.
Of note, the degree of de-repression of the NdgWT- GFP reporter in CHES-1-like null mutants is lower than that of the Ndg Fkh1+2+3-GFP or Ndg Fkh2+3- GFP reporters in wild-type embryos (Fig. 3; supplementary material Figs S3, S4).
Similar(57)
Overall autophagy levels in lkb1 mutants are lower compared to those of wt siblings: while expression of autophagy related proteins is progressively upregulated following yolk depletion in wt larvae, induction of autophagy in lkb1 mutants is strongly attenuated.
The rate of emergence of phage-resistant mutants was lower for phage phT4A when compared with phage ECA2 and phage cocktail phT4A/ECA2.The results indicate that in addition to the efficacy, the potential development of phage-resistant mutants must also be considered in the design of phage cocktails.
Moreover, the optimum pHs of the G276K, G276Y, and G276N mutants were lower than that of the wild type.
However, the numbers of infective juveniles produced on all mutants were lower than that on the wild type (Fig. 4B), and no infective juveniles were produced on purL−.
As expected, the caspase activities in both the cmp1Δ and crz1Δ mutants were lower than that in wild-type cells (Fig. 4B).
It is noteworthy that the fertilization success rate of the mutants was lower than that of the controls, suggesting there may be some defects in the mutant oocytes that affected their fertilization.
The expression levels of both F857-L mutants were lower than the wild type constructs, but no significant difference in the S1/S2 cleavage was observed (Fig. 3b, lane 9 12).
In Figure 7C, the mutants are lower because we used the membrane fraction for the proteinase K protection assay.
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