Sentence examples for mutations in brain from inspiring English sources

So far, it has identified mutations in brain and lung cancers, also reported in Nature in September and October.

Few studies have evaluated mtDNA mutations in brain cancer.

In summary, we report the first large series analyzing EGFR, KRAS, BRAF, and HER-2 mutations in brain metastases of NSCLC.

32 In particular, clinical evidence has shown clonal DNA mutations in brain tumours, 33 34 35 36 implying that DNA damage could be the initiating event.

The aim of this study was to determine the frequency of EGFR, KRAS, BRAF, and HER-2 mutations in brain metastases from non-small cell lung carcinomas (BM-NSCLC).

Eighty-seven genes that have been screened for mutations in brain tumours were annotated for this pathway, of which 26 genes were observed to be mutated (Q-value <0.001) in at least one of the mutated gene data sources, which suggests the involvement of this pathway in brain tumours.

Recent studies have identified a number of causal mutations in brain-expressed genes and have revealed the considerable role that genetics plays in neurological and psychiatric disorders.

Mechanistic data supporting early-life susceptibility to DNA damaging mutagenic chemicals include increased formation of DNA adducts after exposure to vinyl chloride (Laib et al. 1989; Morinello et al. 2002a, 2002b), increased induction of micronuclei in fetal tissues (Hayashi et al. 2000), and increased mutations in brains of transgenic mice exposed to ethylnitrosourea (ENU; Slikker et al. 2004).

In an attempt to clarify the origin of this phenomenon, we have developed an inducible transgenic mouse model with expression of the most common HGPS mutation in brain, skin, bone and heart to investigate how the mutation affects these organs.

29,33,34 In addition to frequent mutation in brain cancers,, approximately 10% of acute myeloid leukemias have an IDH1 mutation, which also produces 2HG and segregates with a distinct epigenetic signature., Mutation of the arginine at position 172 of the closely related IDH2 gene is thought to cause CIMP via a similar mechanism.

Molecular and cellular mutations in the brain can cause brain tumors and lead to cancer.