Sentence examples for mutant in brain from inspiring English sources

In order to clarify this discrepancy, we assessed the cleavage of this mutant in brain of transgenic mice expressing secPrPC in Prnp−/− mice [41].

Previously, our collaborator reported that the PET imaging with morpholino-[I]IPQA, which could irreversibly and specifically bind to active form of EGFR kinase, allowed for identification of tumors with high EGFR kinase signaling activity (i.e., A431 highly expressing EGFR in NSCLC and U87 del EGFR cells expressing EGFRvIII mutants in brain gliomas) [ 28].

Here we describe a highly sensitive time-resolved Förster resonance energy transfer (FRET) assay for quantification of soluble mutant huntingtin in brain, plasma, and cerebrospinal fluid.

For example, expression of mutant huntingtin in brain-derived cells reduced the processing of the sterol response-element binding protein (SREBP; the master regulator of the cholesterol biosynthetic pathway) (Valenza et al., 2005).

APP23 mice over-express the FAD mutant human APP in brain, and develop amyloid plaques similar to the human pathology [8].

CC2D1A was previously shown to associate with PDE4D5 even in the CC2D1A mutant cells and in brain tissue [ 17].

They are also characterized by the presence of widespread nuclear inclusions of mutant polyQ-Htt in brain neurons.

Acridine orange staining showed that at 48 hpf, when wild-type embryos have very few apoptotic cells, such cells were abundant in mutants, especially in brains (Fig. 1D,E).

Total Thr668Ala mAPP in knock-in mutant mouse brains was identical in levels and distribution except that, as expected, there was no detectable phospho-mAPP (Fig. 5).

Finally, despite the apparent neurological or neuromuscular nature of the complication we found no clear morphological differences between mutants and controls in brain or muscle, suggesting that the defect is subtle and/or is physiologic rather than structural.

The accumulated p62 in mutant brain is located in insoluble inclusion bodies that also contain ubiquitinated protein.