Even medical oncologists can be daunted by the complexity of these genes and the therapies intended to fight them, said Dr. William Pao, a physician and scientist at Vanderbilt University who studies cancer mutations in addition to seeing patients.
Moreover, gene mutation analysis revealed that lesions acquired resistance via secondary KIT mutations in addition to primary KIT mutations.
Whole-genome DNA and RNA sequencing found no recurrent mutations in addition to SMARCB1 that would explain the differences between subgroups.
The presence of TSC2 mutations, in addition to TSC1 mutations, underlines the involvement of mTOR signaling in UC.
Our sequencing approach allowed the identification of three new mutations in addition to the enumeration of tandem repeat copies.
Moreover, Acquisti et al. hypothesized that regular point mutations, in addition to hypermutable CpGs, are an important justification for the presence of nullomers/unwords [4].
Strains yC03.1 and yC15.1, containing PHO5 UASp1 and UASp2 mutations in addition to Pho4-MNase, were derived from yC01.2 by homologous recombination with plasmids pCM46.9 and pCM65.1, respectively.
We tested for the presence of mutations in addition to those at codon 436, 437, 540, 581, and 613 of dhps by direct sequencing.
The excess of haplotype and haplotype diversity are likely to be due to the presence of homoplasies (recurrent mutations) in addition to time spacing (the number of haplotypes exceeds S+1, the maximum possible value in the absence of homoplasy or recombination).
The goal of B-SIFT is to enable prediction of activating mutations in addition to deleterious mutations that SIFT already predicts, and so we sought out a large-scale mutagenesis dataset with experimentally verified phenotypes for use in validation of B-SIFT's utility.
