Sentence examples for mutations demonstrate that from inspiring English sources

The analysis of previously reported C-terminal Vpr mutations demonstrate that they do not alleviate the block of IL-12 secretion.

Pigment assays on Su var) mutations demonstrate that strong suppression corresponds to drosopterin levels about six to ten fold higher (75 98% of the amount found in wild-type strains), moderate suppression four to five fold higher (50 75%) and weak suppression two to three fold higher (30 50%), than that observed in the normal wm4 strain.

Importantly, the phenotypes of selected sltA and sltB mutations demonstrate that suppression of null vps mutations is not dependent on the inability to tolerate cation stress.

More recently, studies using a knock-in approach to mimic clinically observed Kit mutations demonstrate that expression of the mutant receptor results in ICC hyperplasia and GIST formation in mice [56], [57].

Experiments conducted following site-directed mutations demonstrate that aspartate residue (Asp) phosphorylation is interfered with by either mutations involving the TMBS or the sixth NMBD copper site (Supplementary Figure S7 at http://www.biochemj.org/bj/463/bj4630167add.htm), whereas inhibition of serine phosphorylation is only observed following mutation of the sixth NMBD copper site.

Only one case presented a BRAF mutation, demonstrating that is a rare alteration in EAL.

Screening of mutations demonstrates that the C-domain (residues 29 40 (42)), the median domain (residues 17 22) and the N-domain (1 16) are all crucial for interaction.

Surprisingly, all six residues correspond to sequence positions associated with drug resistance mutations, demonstrating that the very residues that are responsible for native substrate specificity in HIV-1 protease are altered during its evolution to drug resistance, suggesting that drug resistance and substrate selectivity may share common mechanisms.

In fact, in the past decade, forward genetics has uncovered mutations demonstrating that certain genes exist only in mammals, that specific mechanisms function only in mammals, and that particular biological processes may exist only in mammals; hence screens focused on these processes have identified unsuspected genes.

Examination of the published KLF6 mutations demonstrates that indeed a number of the cancer-defined mutations occur in the NLS and NES domains (Figure 8).

Analysis of mucA mutations demonstrated that 75% corresponded to the mucA22 allele, with the remaining 25% being represented by C-to-T transitions (Table 1 and Figure 2C).