Sentence examples for mutations demonstrates that from inspiring English sources

Screening of mutations demonstrates that the C-domain (residues 29 40 (42)), the median domain (residues 17 22) and the N-domain (1 16) are all crucial for interaction.

Examination of the published KLF6 mutations demonstrates that indeed a number of the cancer-defined mutations occur in the NLS and NES domains (Figure 8).

Moreover, comparison of the K a / K s results versus known drug-resistance mutations demonstrates that this approach predicts true drug-resistance mutation codons with a high level of accuracy (13 drug-resistance mutation codons in K a / K s analysis, and 19 in the conditional K a / K s analysis).

On the other hand, examining the same regions for mutations that have substantially propagated into human populations (i.e. medium and high frequency SNPs as well as "fixed" recent mutations) demonstrates that these fixed or nearly fixed substitutions are much less prone to G or C → T or A changes.

Only one case presented a BRAF mutation, demonstrating that is a rare alteration in EAL.

Surprisingly, all six residues correspond to sequence positions associated with drug resistance mutations, demonstrating that the very residues that are responsible for native substrate specificity in HIV-1 protease are altered during its evolution to drug resistance, suggesting that drug resistance and substrate selectivity may share common mechanisms.

In fact, in the past decade, forward genetics has uncovered mutations demonstrating that certain genes exist only in mammals, that specific mechanisms function only in mammals, and that particular biological processes may exist only in mammals; hence screens focused on these processes have identified unsuspected genes.

The analysis of previously reported C-terminal Vpr mutations demonstrate that they do not alleviate the block of IL-12 secretion.

Analysis of mucA mutations demonstrated that 75% corresponded to the mucA22 allele, with the remaining 25% being represented by C-to-T transitions (Table 1 and Figure 2C).

Controls spiked with each of these two deletion mutations demonstrated that one mutant molecule can be detected in 1.7 3.3 µg gDNA (0.5 1×106 genomes) and that the samples lacked inhibitors at the concentrations of genome utilized.

Pigment assays on Su var) mutations demonstrate that strong suppression corresponds to drosopterin levels about six to ten fold higher (75 98% of the amount found in wild-type strains), moderate suppression four to five fold higher (50 75%) and weak suppression two to three fold higher (30 50%), than that observed in the normal wm4 strain.