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Studies in Emx2 −/− null mutants demonstrate that the projecting neurons originating from layer VI are ectopically guided along the boundary of the cortex and striatum with a wider distribution compared to the axon bundle observed in control mice.
The opposing morphological and molecular phenotypes in betaglycan heterozygote and null mutants demonstrate that the levels of betaglycan must be tightly regulated for optimal kidney development.
Analyses of other similar double mutants demonstrate that genes involved in myoblast fusion might interact with each other to affect fusion efficiency.
The similar levels of ROS production and alkalinization triggered by the ΔrfaH and ΔinvA mutants demonstrate that the oxidative burst depletion stimulated by WT S. Typhimurium requires a functional TTSS-1.
Phenotypic analyses of yar mutants demonstrate that yar is required for both sleep maintenance and homeostasis.
In fact analyses of other PDB-associated mutants demonstrate that the relationship between SQSTM1 protein function, NF-κB activity and PDB severity is more complex than initially anticipated.
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However, SMX had no effect on nuc-1 mutants, demonstrating that animals maintain a functional folate cycle.
The increase was less pronounced with the Ala mutants, demonstrating that introduction of negative charges at the distinct positions in the UNG2 regulatory domain specifically stimulates the activity of UNG2.
Studies using oshkt2 1 null mutants demonstrated that OsHKT2 1 (or OsHKT1) takes up Na+ under K+-starvation conditions [57].
In vivo analysis of smy1Δ mutants demonstrates that this "damper" mechanism is critical for maintaining proper actin cable architecture, dynamics, and function.
The studies of HvCPI, a group I phytocystatin from barley, and a series of its site-directed mutants demonstrated that antifungal activity of HvCPI is not related to its inhibitory property against cysteine protease (Martinez et al. 2003).
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