Sentence examples for mutations could accumulate from inspiring English sources

During the relatively short time spanning the divergences, only a limited number of mutations could accumulate.

Alternatively, mutations could accumulate by Muller's ratchet very rapidly, yet have no effect on fitness, if all mutational effects were sufficiently small.

Duplication and triplication of regions would result in paralogs among which mutations could accumulate resulting in what would simply look like a heterozygote among Illumina reads.

We hypothesised that breast tumours with TP53 mutations could accumulate genetic alterations leading to complete tumour response through mitotic catastrophes and tumour cell death (Huang et al, 2005).

Therefore, increased mutations could accumulate in osrecql4 mutant plants during the mitotic cell cycle, and these mutations should be inherited by subsequent generations.

Mutations could accumulate in non-dividing cells [ 42], thus making tumors with low proliferation indices e.g., grade II (DA) tumors accumulating more mutations than grade IV (GBM) tumors.

and intrinsic factors (DNA replication errors, spontaneous chemical changes to DNA, programmed DNA recombination) can lead to mutations, which could accumulate over time in the progenitor population.

Yet, the amount of variability for substitution rate in LTRs remain high to the point that even LTRs belonging to the same element could accumulate mutations with a 2-fold differential rate between them.

19 Our results support the hypothesis that mtDNA could accumulate mutations as a result of damage from reactive oxygen species, determining an impairment of oxidative phosphorylation and neurodegeneration.

In fact, new genes could accumulate mutations faster in late-replicating and heterochromatic regions (Stamatoyannopoulos et al., 2009; Pink and Hurst, 2010), since compact chromatin seems to be prone to suffer DNA damage due to replicative stress (Sulli et al., 2012; Alabert and Groth, 2012).

Collectively, these data indicated that the ectopic Id2 and its mutants can effectively be expressed in MCF-7 and SKOV-3 cells and with the D-box mutation transfection, Id2 protein could accumulate to a much higher level than with the wild type.