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For 12 of the mutants located at the protein lipid interphase, we used the von Heijne water membrane transfer scale, and we find that 9 of the mutations could affect membrane insertion.
Synonymous mutations could affect the stability and secondary structure of RNA.
Attention has been focused on how mutations could affect these steps of SOD1 maturation.
We tested if H. pylori fur mutations could affect resistance to metronidazole (Mtz), an anti-H.
However, whether CFTR mutations could affect spermatogenesis and result in azoospermia remains an open question.
The results suggested that the mutations could affect the incorporation of RT into the viral particles, leading to a defect in reverse transcription which initiates viral replication.
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It was reported the I675V mutation could affect some physicochemical properties of MPER which contribute to increased immunogenicity.
We considered the possibility that the vig mutation could affect the expression of Su var)205 (most likely indirectly) and tested Su var)205 RNA levels by RT-PCR.
The α-adducin gene (4p16.3) point mutation could affect renal sodium transport and explain a large proportion of blood pressure (BP) variation [3] [5], suggesting the involvement of mutated adducin variants in sodium-dependent hypertension.
Alternatively, the mutation could affect N-linked glycosylation of the SEA domain that may affect protein stability.
Such a mutation could affect the synthesis of the Imp-βKetRE34 protein and weaken the dominant negative phenotype.
More suggestions(15)
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