Sentence examples for mutations could arise from inspiring English sources
We applied this concept to human cancer, hypothesizing that oncogenic mutations could arise in gaps in personal MHC-I presentation.
Overall, however, we consider it highly unlikely that two somatic mutations could arise in relatively young coral colonies (<40 cm in diameter), and thus our conservative estimate of chimerism based on two non-shared alleles should avoid scoring colonies as chimeras that were in fact mosaics.
The two mutations could arise in completely independent subclones, in which case reads could report either variant alone but never the two together.
New mutations occurred uniformly and at random across the genome; thus mutations could arise at an already polymorphic site, allowing both "double hit" mutations (if occurring at an ancestral allele) and "back" mutations (if occurring at a derived allele), although these types of mutations were extremely rare.
For example, in the case of the glucocorticoid receptors, it was inferred that neutral mutations that stabilized a new conformation must have been acquired before the specificity-shifting mutation could arise in the receptor's active site (Ortlund et al., 2007).
However, it must be kept in mind that sporadic mutations of p53 could arise from selective pressure in the cells upon prolonged nutlin treatment, rendering a state of resistance towards the drug [ 63].
However, our model does not preclude that mutations could subsequently arise due to cytoarchitectural dislocations in the aberrant cells.
Alternatively, resistance could arise from mutations in rare cells possessing stem cell attributes.
We did not include in our analysis the vast number of Gcd– mutations, because a Gcd– phenotype could arise not only from an impaired mode of binding to unphosphorylated eIF2 but also from lower eIF2B activity or stability.
One could envisage a situation where at some point the populations will become large enough so that other types could migrate or could arise by mutation.
In the previous hypothetical example, a new allele could arise by mutation capable of increased heat removal without negative effect on the viability of the organism.
