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The probability of a He atom escaping into vacuum from a trap mutation depends on the type of the trap mutation, and the occurrence probabilities of the different types of trap mutations are dependent on the temperature.
EGFP positive cells are obtained in the absence of vector replication demonstrating that the mutations are dependent only on the mismatch repair (MMR) pathway.
To test the hypothesis that TGFBR2 and ACVR2 frameshift mutations are dependent on the human MMR background, we constructed EGFP plasmids in which a −1 bp frameshift mutation at coding microsatellites of TGFBR2 exon 3 and ACVR2 exon 10 was detected by EGFP expression in human colon cancer cells with MMR deficiency.
We hypothesized that substrates for ubiquitylation by BIRC3 are likely mediators of BIRC3-driven transformation, with NIK in particular being a promising mediator given that it is directly ubiquitylated by BIRC3 (12) and that cells that harbor BIRC3 mutations are dependent on NIK for survival.
A key question for efforts to assess pandemic risk of non-human viruses is the degree to which certain substitutions are general markers for a phenotype, or whether the impacts of those mutations are dependent on genetic context and/or specific non-human host.
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Our study suggested that spaceflight induced mutations were dependent on different rice varieties.
The presence of back mutations is dependent on the mutation rate and the divergence time [ 16].
Statistical analysis revealed that G1613A and C1653T mutations were dependent on each other.
In the pre-NGS era, the identification of damaging mutations was dependent on labor- and cost-intensive Sanger sequencing.
Interestingly, the selective effect of these mutations was dependent upon both the carbon source and the growth rate of cells.
Stability-mediated epistasis therefore constrains NP's adaptation as well as its sequence evolution, since the accessibility of immune-escape mutations is dependent on the acquisition of enabling mutations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com