Sentence examples for mutants are dependent from inspiring English sources

It has been documented that certain p53 missense mutants are dependent on chaperones such as HSP90 for their stability.

These findings indicate that altered patterns of Ngn2, Ascl1, and Nkx2.2 expression around the thalamic/prethalamic border of Pax6 −/− mutants are dependent on Shh signaling.

The lesions that develop in edr2 mutants are dependent on the SA signal transduction pathway providing an additional link to defense responses.

Accordingly, it is also possible that the defects observed for these phosphatase mutants are dependent on the dynamics of the amino acid pools or changes in the concentration of mevalonate.

Rahman et al. find that the increased longevity of the OGA null mutants are dependent on daf-16, whereas Love et al. find that OGA null mutant extension of lifespan in the daf-2 background is not dependent on daf-16.Both reports show that OGT null mutants have aberrant constitutive nuclear accumulation of daf-16, but Rahman et al. find that the OGA null mutant also has this phenotype.

In summary, the experiments above demonstrate that LTP in the CA1 region of our mutants is dependent on both NMDARs and Ca2+-permeable GluR2-lacking AMPARs.

To ascertain whether MMP-2 epitope presentation from the MMP-2 mutants was dependent on these ERAD components, MMP-2 transfected COS cells were treated with the proteasome inhibitors MG-132 or by the retrotranslocation channels inhibitor: Pseudomonas aeruginosa Exotoxin-A [24], [25].

In vitro, sunitinib activity against KIT double mutants was dependent on location of the second mutation.

The lifespan extension of daf-2 mutants is dependent on the transcription factor DAF-16/FOXO [ 33].

These results suggest that the vasoprotective effect in tie-2 mutants is dependent on normal levels of VE-cadherin.

We first asked whether the stress resistance phenotype of egr-1 overexpression mutants is dependent on DAF-16 activity.