Sentence examples for mutations and provide from inspiring English sources

The process might take tens, or even hundreds, of thousands of years, but Darwinian selection would ultimately favor such mutations, and provide the opportunity for the evolution of a fitter human population.

The study was designed to identify pathogenic TSC1 or TSC2 gene mutations and provide solid evidence for the diagnosis of tuberous sclerosis complex (TSC).

These data indicate that NRR antibodies are capable of recognizing and stabilizing Notch1 receptors bearing common class I mutations, and provide additional support for the idea that juxtamembranous insertional mutations activate Notch1 through a mechanism distinct from that of class I mutations [35].

The results show a close correlation with reduced activity among the corresponding mutations, and provide evidence that the L, M, and N subunits have a common role in Complex I. Complex I (NADH ubiquinone oxidoreductase) is the initial electron acceptor of the mitochondrial respiratory chain, and it is a key member of the electron transport chains of many bacteria (for a review see [1]).

Because the conservation-mutation correlation analysis is based on the correlation analysis of amino acid mutations, the CMCA approach may find applications in rational protein design and enzyme engineering by means of artificial residue mutations, and provide suggestion to improve the bioactivities and physicochemical properties of enzymes.

These organelles, Allen proposed, are transcriptionally and energetically repressed, accumulating far fewer mutations, and provide an accurate source of information for mitochondria in the next generation.

It describes what functional changes occur upon RGS mutations and provides mutation site information.

Our study suggests that miRNAs may contribute to the pathogenesis of FTLD-TDP caused by PGRN mutations and provides new insight into potential future therapeutic options.

In order to confirm our previous findings (Ermakov et al., 2009), a congenic C3.C- gpg6 strain was generated, segregating away additional mutations and providing a defined, homogeneous genetic background.

In each case, electron density maps, inspected using COOT, were consistent with the expected point mutations and provided clear evidence of ligand binding at the donor pocket.

Logistic regression models were used to detect associations of these characteristics with each of the specific KRAS mutations and provided estimates of odds ratio (ORs) and confidence intervals (CIs).