Sentence examples for mutations and be from inspiring English sources

Although Kras Codon 12 GAT is a single mutation in a single oncogene, DNA mutations in other oncogenes, if they occurred with Cr VI) exposure, may be expected to amplify Kras mutations and be detected in the ACB-PCR assay.

TEs are present within insect ESTs and mature transcripts of D. melanogaster, and can cause alternative the modification of cis-regulatory function, introduction of frameshift and premature stop codon mutations, and be involved in exon shuffling or insertion of introns.

Let R be the ratio between the number of transitional mutations and that of transversional mutations and be estimated from external information (e.g., from nonoverlapping regions or other genes).

These results might explain why individuals with TSC rarely have malignant tumors, but also suggest that cancer arising in individuals without TSC might be influenced by the status of TSC1 and/or TSC2 mutations and be potentially treatable with mTORC1 inhibitors.

We suggest two possibilities for the missing genes: 1) Either the missing genes were recently lost, in which case the pathway is no longer intact and we would expect the remaining genes with no other roles will eventually accumulate mutations and be lost, or 2) a diverged homologous gene or a nonhomologous neofuncionalized gene may take the place of the missing gene and keep the pathway intact.

Mutations that confer a fitness advantage to the cell are known as driver mutations and are causally related to tumorigenesis.

All mutations were different missense mutations, and were shown to occur de novo.

The neutral theory considered that genetic variations were accumulation of neutral mutation, and were removed by genetic drift (Kimura, 1968).

The protein is thought to have appeared after a spontaneous genetic mutation and was found after a tissue sample was submitted for testing by the World Animal Health Organization (OIE).

Thirty-nine patients had H63D mutation and were all heterozygous.

Additionally, it induces DNA mutation and is carcinogenic to humans.