Sentence examples for mutations and replace from inspiring English sources
That has spurred research on how to strip out mitochondria with genetic mutations and replace them with healthy mitochondria.
Corrected DNA can be engineered to fix a single mutation, or knock out and replace an entire gene.
Beneficial mutations will increase in frequency and replace the less fit variants.
However, they have not succeeded until now in cutting out mutations and precisely replacing them with healthy strands of DNA, said Alexander Marson of the University of California, San Francisco, who led the latest research.
This latest study (whose lead author was Hong Ma and senior author was Shoukhrat Mitalipov, both from the Oregon Health and Science University) demonstrated how CRISPR-Ca9 can cut out a genetic mutation responsible for hypertrophic cardiomyopathy and replace it with a normal genetic sequence.
For patients carrying genetic mutations related to ALS, genetic corrected stem cells could be generated to correct the mutation, and for those carrying no genetic mutation, the protective and replacing effect of allogeneic stem cells are available.
We generated random mutations by using PCR and replaced the wild-type copy of RPB2 with the mutant alleles via plasmid shuffle in a yeast strain deleted for the chromosomal RPB2 locus (Materials and Methods).
2. The location of the point mutation and the replaced nucleotide (e.g., G15U).
The PEP-dependent phosphotransferase system was deactivated by a spontaneous point mutation and functionally replaced by the GalP permease and glucokinase.
In order to elevate mutation rate MSH2 was deleted and replaced with URA3 in each of the four haploids used to create the diploid mutator strains using the standard Lithium Acetate transformation method.
As BAFF-inhibitory therapy targets external signals, it is probable that MMCs treated with this kind of therapy will develop mutations that replace the need for external BAFF stimulation, and that these subclones will be positively selected.
