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The researchers also discovered that different mutation patterns were associated with varying levels of risk for developing AML and for when the disease emerged.

Differences between the organs with respect to the spontaneous mutation patterns were observed.

The mutation patterns were listed in Table 2.

A total of 25 QRDR mutation patterns were found (Table 3).

However, isolates within the same PFGE cluster having the same ST but different QRDR mutation patterns were also found.

According to the classification of Dabernat et al. [ 22] different mutation patterns were identified among BLNAR and BLPACR strains.

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Similar(47)

However, the influence of most mutator alleles on mutation patterns is not understood at this level.

The effects of selection on the observed mutation patterns are most pronounced in relatively slowly mutating, non-CpG sites.

This, in turn, indicates that multifactorial studies on mutation patterns are necessary to uncover mutation processes in insect mitochondrial genomes.

Moreover, the observed mutation patterns are not accounted for by known patterns of DNA methylation in fungi.

Close linkage to tumor specific mutation patterns is necessary to unambiguously identify low frequency passenger mutations as evidence of ongoing mutation within shifting dominant tumor subclones.

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