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Exact(6)
But a second kind of mutation occurs more rapidly and the combination of the two may make a reasonable clock.
New alleles will often arrive in a population as a singlet, and extinction is permanent unless the same mutation occurs more than once.
Therefore, the C to T mutation occurs more frequently in the leading strands than in the lagging strands and then the excesses of G relative to C and T relative to A are formed in the leading strands.
In conclusion, PIK3CA mutation occurs more frequently in elder patients and the ratio of mutations in hot spots to non-hot spots is about 2.5 to 1 in HER2-positive breast cancer patients.
Also it is generally observed that a mutation occurs more often at C: G than A: T and that a C: G appearing in CpG dinucleotides has a higher mutation rate than a C: G appearing in non- CpG dinucleotides.
Therefore, the C to T mutation occurs more frequently in the leading stand than in the lagging strand and the excesses of G(C) relative to C(G) and T(A) relative to A(T) are formed in the leading(lagging) strand.
Similar(54)
In accordance with previous reports (Kim et al, 2006; Deng et al, 2008; Zlobec et al, 2010), BRAF mutation occurred more frequently in right-sided tumour locations.
If the comparison was made separately for these two groups, the mutation occurred more frequently in higher- than in lower-risk MDS.
TP53 mutation occurred more frequently in carcinomas than borderline tumors (56.8 % and 11.5 %, respectively), and combined IHC and mutation data suggest alterations occur in approximately 68 % of MC and as many as 20%% of MBOT.
Among the FISH-positive samples, EGFR gene mutation occurred more frequently in samples with gene amplification compared to those with high polysomy, suggesting that EGFR mutation and gene amplification should be used as clinical decision parameters to predict response to EGFR-targeting therapy.
From this data set, we cannot determine why some of these "hotspots" are mutated and others are not, or why some mutations occur more frequently.
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