Sentence examples for mutation affects more from inspiring English sources

However, it is also possible that the mthΔ6 mutation affects more than just the mth locus; a deleterious effect by another gene would likely compromise longevity.

In both water soluble and odorant assays there is a degree of redundancy; only mutations affecting more than one cell significantly impair soluble chemotaxis.

The most striking result observed in our database was the fact that KRAS mutations affected more women compared to men (34.8% vs. 32.5%, respectively, p = 0.03) as can be seen in Table  4.

These results suggest that this mutation in CYK-4 affects more than the RhoGAP activity of CYK-4 or that CED-10/Rac1 is not the relevant target of the GAP domain, or both.

The second determinant will be the timing when the trigger hits its target: an early hit during vasculogenesis (such as a germinal mutation) will affect more cells and will lead to a metamerically arranged defect, whereas a late hit (such as a somatic mutation that occurs late during the fetal life or even postnatally) will have a more focal impact on the vessel [ 3].

When the mutation affects the active site, more sophisticated and time-consuming Quantum Mechanical computational techniques should be used.

Navascués and Emerson (2005) recommended the use of Nei's unbiased haplotype diversity (Nei, 1978) over the measure developed by Goldstein et al. (1995), which assumes a pairwise mutation model and is affected more severely by homoplasy.

More precisely, the HX mutation affects the majority of Hox-TF interactions.

Nevertheless, the pooled analysis of the misregulation of all targets of TP53 across all tumor types reveals that although in most cases truncating mutation of the TF do affect more the expression of its targets than missense mutations, the differences are clearly significant only in breast tumors, glioblastomas, and low grade gliomas (Additional file 1: Figure S4).

This suggests that F1174L mutation affects the binding of crizotinib and makes the backbone more flexible to move.

The final number of mutations which were defined as truly somatic affected more than 1000 genes.