Sentence examples for mutation may promote from inspiring English sources

Further, in prior publications, we have shown that targets downstream of 185delAG, including maspin, are unaffected when 185delAG is itself mutated to generate a further BRCA1 mutation [ 39] suggesting that the 185delAG BRCA1 mutation may promote tumorigenesis by a unique mechanism.

These data suggest that the FYVE-CENT R1945Q mutation may promote carcinogenesis by interferring with normal cytokinesis.

Our data suggest that increased ferritin levels, associated with age, gender, and HFE subtype C282Y gene mutation, may promote cartilage damage with knee OA.

It was predicted in a modeling study (17) that the V510D mutation may promote NBD1−TMD2 interactions in ΔF508-CFTR by forming a salt bridge with positively charged residue Arg1070 (TMD2).

Even though deleterious mutations usually outnumber beneficial mutations, an increased rate of mutation may promote adaptation in stressful environments, where fluctuating selective pressures favor phenotypic change (Taddei et al. 1997; Tanaka et al. 2003).

Presumably, these mutations may promote enhanced DOX mediated ROS production and/or allow greater access of DOX into the mitochondrial compartment.

Bcl2 inhibition of mtDNA repair and enhancement of mtDNA mutations may promote tumorigenesis following exposure to carcinogens (i.e. NNK) or reactive oxygen species.

Furthermore, the suppressor protein p53 is mutated in HT-29 cells (Goldberg et al, 1996; Gobert et al, 1999) and recent data showed that p53 mutations may promote cancer progression by augmenting NF- κB activation in the context of chronic inflammation (Weisz et al, 2007).

An abnormal chromosome number alone can induce mutations that may promote cancer initiation or progression.

The mitochondrial genome has been identified as a possible target for somatic mutations that may promote tumorigenesis [ 2- 10].

It is tempting to suggest that this missing arginine in Her2 may explain its weak ectodomain heterodimerization compared to the homodimerization of dEGFR, EGFR, and Her4, and that an L291R mutation in Her2 may promote Her2 heterodimerization and facilitate the crystallization of a Her3–Her2 or EGFR–Her2 dimer.