Sentence examples for mutation may predict from inspiring English sources

This mutation may predict resistance to PI3 kinase inhibition (and conceivably receptor tyrosine kinase inhibition) in some contexts [16].

The presence of a KRAS mutation may predict lack of response to EGFR inhibitors in metastatic CRC [ 11, 13, 14].

Recent work by Tsao et al (2005) suggest that among patients with non-small-cell lung cancer receiving erlotinib, the presence of an EGFR mutation may predict for responsiveness to the agent; however, it was not indicative of a survival benefit.

In the not-so-distant future, BRCA1 mutations may predict mastectomies, not breast cancer.

Lynch et al (2004) and Pao et al (2004) also showed that cancer cells transfected with EGFR gene mutations showed enhanced tyrosine kinase activity in response to binding of epidermal growth factor and increased sensitivity to gefitinib and erlotinib, suggesting that specific EGFR mutations may predict responsiveness to this type of treatment.

In addition, IDH mutation status may predict benefit from alkylating agent when combined with MGMT promoter methylation assessment [ 13].

Also, K-Ras mutation status may predict time to progression in patients treated with irinotecan and oxaliplatin.

Several tumors harbored mutations that may predict response to investigational agents.

Another potentially important use of CTCs for biomarker analysis is detection of oncogenic mutations that may predict response to targeted agents [1].

EGFR mutations that may predict sensitivity to EGFR inhibitors have been identified in TNBC as well.

Therefore, it is important to find biomarkers in mutation carriers which may predict the development of the clinical symptoms.