Sentence examples for mutation may disrupt from inspiring English sources

This mutation may disrupt an inactive conformation of BRAF kinase.

The T135A mutation may disrupt the hydrogen bond pattern in the loop.

It is conceivable that the familial D620N mutation may disrupt the proper retromer-dependent trafficking of cargo proteins.

Neurotrophin-3 (NT-3) from GrCs is required for PC dendritic morphogenesis (Joo et al., 2014), suggesting the possibility that the Shank3+/ΔC mutation may disrupt PC dendritic function.

Alternatively, the mutation may disrupt the conformation of the NES, which has been shown to adopt an α-helical structure in other proteins (30, 31), thus preventing binding to CRM1.

In addition, non-catalytic mutations may disrupt protein binding to other domains, as described above.

This has led us to suggest the hypothesis that these mutations may disrupt interactions between CBS and other proteins, which are important for its cellular functions.

Alternatively, the two mutations may disrupt an interaction or property of Tti2 that otherwise results in its inhibition.

For example, certain oncogenic mutations may disrupt key regulatory pathways that control genomic fidelity, apoptosis and proliferation.

Although yeast cells grown on glucose do not rely on respiration and do not utilize mtDNA, mutations may disrupt integrity of mtDNA, so it may be lost.

More importantly, we speculate how nesprin mutations may disrupt tissue specific nesprin scaffolds and explain the tissue specific nature of many nesprin-associated diseases, including laminopathies.