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Exact(7)
Direct competitions with a wild-type strain confirmed that a ΔwzxE mutation is neutral in media without drug and deleterious in both nalidixic acid and amikacin (Figure 2).
To assess the strain's fitness more sensitively, we subjected the folM::kan strain to direct competition with the wild-type strain and found that the folM::kan mutation is neutral without drug and beneficial in the presence of trimethoprim (Figure 2).
Conversely, the lower the score, the greater the confidence that a mutation is neutral.
To perform these estimations we tried to distinguish if a mutation is neutral or not.
In contrast, the citT mutation is neutral or possibly slightly beneficial to fitness when the gltA1 mutation is present.
Whether a mutation is neutral or lethal is decided based on unfolding and misfolding stabilities of the resulting amino acid sequence.
Similar(53)
We assume here that synonymous mutation are neutral and that the synonymous divergence gives an estimate of the mutation rate; although, there is a discrepancy between mutation rate estimated from pedigrees and the level of synonymous divergence, this is probably a consequence of the methods used to infer the pedigree mutation rate [17].
The cumulative effect of mutations is neutral and not transformative in vast majority of normal cells since the mutational effect follows a Gaussian distribution as proposed by our model.
A large amount of mutations is neutral: 53.07%.
But most mutations are neutral in their effect.Sexual reproduction mixes up the DNA, distributing neutral mutations around the population.
Most of the spontaneous mutations are neutral or deleterious, while disadvantage mutations will be discarded, and neutral mutations can still retain.
Related(18)
mutation is free
move is neutral
variation is neutral
evolution is neutral
mutation is independent
mutant is neutral
mutation is present
mutation is responsible
mutation has neutral
mutation is random
mutation is standard
mutation is frequent
mutation is beneficial
mutation is likely
mutation is unknown
mutation is bad
mutation is rare
mutation is silent
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