Whether such a mutation is likely anytime soon is unknown.
By contrast, I argue that germline mutation is likely to be a very weak balancing force in evolutionary dynamics.
Thus, the T122K mutation is likely to have an impact on the assembly of tetrameric 2 AGA and, consequently, on the activation of the enzyme.
This mutation is likely an adaptation to Vero cell as we have derived DN-2 through minimal number of in vitro passages.
A project leader, Dr. Eric Reiman, director of the Banner Alzheimer's Institute in Phoenix, said testing on as many as 2,000 people, including about 750 with the mutation, is likely to begin late next year or early in 2012.
As the PKC phosphorylation sites on cytoplasmic domain (intracellular side) of hDAT are structurally far away from the residue H547 on the extracellular side of hDAT37,38, the H547A mutation is likely to regulate the PKC-mediated phosphorylation by allosteric effect.
Introduction of a longer side chain at position 665 by the L665F mutation is likely to generate hydrophobic interactions with the side chains of some of the above-mentioned residues.
In addition, since an allele of qSH1 is found only in the temperate japonica subspecies, this natural mutation is likely to have been selected during the domestication of japonica rice [16].
Since the selected sh4 allele was found in all examined landraces and modern cultivars of both indica and japonica rice, the sh4 mutation is likely to have been utilized during the very early stages of the rice domestication process.
The mutation is likely to facilitate adult-type GCT development and may possibly be the tumor's primary cause.
Our model predicts that the cancer-associated p.Cys134Trp mutation is likely to affect the protein/protein homotypic interaction.
