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The IDH1 R132H mutation is mainly mutated in secondary GBMs (89.9%), and it is observed with low frequency in primary GBMs (15.3%).

However, the NRAS mutation is mainly found in LSCRC [ 29].

EGFR mutation is mainly observed among patients with adenocarcionoma, never-smokers, and Eastern Asian ethnicity.

This gene mutation is mainly related to the pancreatic intraepithelial neoplasia but rarely lead to invasive PDAC.

This implies that the higher force in the presence of the mutation is mainly caused by an increase in the proportion of myosin heads that are strongly bound to actin filaments rather than a change in the force developed by individual cross-bridges.

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In most previous studies K-ras gene mutation was mainly assessed by PCR.

In this study, mutation was mainly adopted to improve the bacterial flora's growth and activity.

Taken together, these results indicated that the loss of function of the G64D mutation was mainly attributable to a large reduction in the quantity of the mature ZIP13 protein, rather than to a disruption in ZIP13's ability to form a complex due to a change in its biochemical characteristics.

However, this prognostic effect of KRAS mutations is mainly observed in adenocarcinomas of the lung (Slebos et al, 1990; Mitsudomi et al, 1991; Sugio et al, 1992).

This interference among mutations is mainly determined by the rate of beneficial mutations, which in turn depends on the population size, the total error rate, and the degree of adaptation of the population.

A possible interpretation of the data could be that the extremely high UV-induced death rate in the embryos with the XP/CS mutations is mainly caused by UV-induced strand displacement in XP/CS cells (Godon et al., 2012), whereas the modestly elevated rates seen in most XP and TTD mutants might reflect reduced NER.

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