Sentence examples for mutation in combination from inspiring English sources

In addition, the mutation rates of strains with the pol2-4 mutatinn in combination with active site mutator mutations in Pol δ and Pol α suggest that Pol ε may proofread certain errors made by Pol α and Pol δ during replication in vivo.

Finally, enzyme kinetic and thermal stability analyses revealed that the p.Leu77Arg mutation or the p.Leu77Arg mutation in combination with the p.Val101Met mutation inactivates GCK function and stability, while mutation of p.Val101Met alone does not.

Moreover, while spt16-m mutation led to a mildly reduction of Sir2 4p binding at heterochromatin region, this mutation in combination with cac1Δ rtt106Δ led to a dramatic reduction of Sir2 4p binding comparing with either single or double mutant cells (Fig. 2A).

In Y. pestis, genetic divergence appears to be driven by gene decay via insertional and point mutation, in combination with selective genome expansion by lateral gene transfer among plasmids.

Interestingly, a TPI deficiency patient which has inherited a start codon mutation in combination with the mutation at position 104, has a stronger pathology in comparison to Glu104Asp homozygotes [17].

To understand whether similar effects could be also observed for other missense mutants the available primary cultures of skin fibroblasts from 9 MPS IIIC patients carrying missense HGSNAT mutations or a missense mutation in combination with a splice site or nonsense mutation were treated with glucosamine and assayed for N-acetyltransferase activity.

The p.D444H mutation alone is a "milder" mutation and in combination with a mutation for profound BD on the other allele results in partial BD.

TERC mutations in combination with exposure to environmental factors, such as smoking and obesity, not only quicken the pace of biological aging but also increase a carrier's susceptibility to age-related diseases, thereby resulting in the onset of those conditions relatively early in adult life.

We have further characterised the effects of these two mutations in combination with the Z mutation in a eukaryotic cell model of disease.

Consequently, it is very difficult to predict the long-term ecological impact of transgenes that escape spatio-temporal control, and it may be exacerbated by genetic re-arrangements and newly occurring mutations in combination with environmental (biotic as well as abiotic) changes.

In fact a better characterization of the molecular problems caused by these mutations in combination with may be of help in characterizing different subgroups of sporadic AD patients and help in their treatment.