Sentence examples for mutation a key from inspiring English sources

We also find that we can computationally recapitulate specificity changes upon mutation, a key test for successful forward design of protein protein interface specificity.

We describe a case of aHUS secondary to complement Factor H CFHH) mutation, a key regulator of the alternative complement cascade.

On the contrary, the origin of these new acentriolar cell lines is clearly defined, the DSas-4 mutation, a key regulator of centriole assembly.

When considering the evidence required to determine whether general population screening should be performed for the C282Y mutation, a key factor is the clinical penetrance of C282Y homozygosity.

Although many resistance mechanisms have been clarified, the EGFR kinase domain mutation T790M in exon 20 accounts for nearly half of all acquired resistance, making testing for this mutation a key factor in determining following treatment strategies in the era of second- and third-generation EGFR-TKIs [ 12, 13].

As the vast majority of patients with Parkinson's do not carry rare familial mutations, a key question has been why these individuals with common sporadic Parkinson's nonetheless acquire excess alpha-synuclein protein and lose critical dopamine neurons, leading to the disease.

We and others have previously shown that somatic KRAS mutations (a key effector of the EGFR initiated signaling) can independently impair the efficacy of panitumumab or cetuximab [8] [10].

This in turn induces mutations, a key driver for oncogenic progression.

Besides the intrinsic interactions between mutations, a key extrinsic factor that has been suggested to influence the ruggedness of an adaptive landscape is environmental heterogeneity [ 13- 15, 35, 36].

In contrast, the npr1-1 mutant, which has a mutation in a key domain, is affected in the expression of SA, JA and ET-dependent genes [ 17].

In the past, it was generally thought that genetic mutation was a key event of tumor pathogenesis, especially somatic mutation of tumor suppressor genes.