Somewhat surprisingly, the TRIAP1-SLMO1 couldex could be detected for single point mutants at aromatic residues in TRIAP1, but the double mutant of a key interfacial contact, TRIAP1-F41A/SLMO1-V38A (Fig 2C), abrogated complex formation (Fig 2D, right).
Such a mutant provides a key tool to clarify the molecular function of TTC26/DYF13 because it lets us exploit the advantages of C. reinhardtii as a model organism for biochemical and cellular studies of cilia and flagella.
From the phenotype of the Na-auxotroph tomato mutant chloronerva a key role for nicotianamine in the transport of Fe taken up by the roots to the shoots was postulated [ 39]. Figure 7 reports the changes in the relative spots volume of proteins that were reduced in quantity during Fe deficiency.
Gene engineering for generating targeted mouse mutants is a key technology for biomedical research.
The generation of targeted mouse mutants is a key technology for biomedical research.
How to accurately estimate the differentiation between the wild type and the long-lived mutants is a key problem in our functional genomic study of ageing.
This paper is an extension of our previous study of Physcomitrella knockout mutants of a key MRN (MRE11, RAD50, and NBS1) complex [ 6] with a pleiotropic effect on DSB repair in whole.
Analysis of Vps1 mutants identified a key site (RR457,458) as critical for both actin interaction and endocytic function, while two other mutations (KRR-EEE and E473K) led to defects affecting all functions of Vps1 in addition to endocytosis.
Recently, it has been proposed that a generalized up-regulation of xenobiotic detoxification pathways may be a shared feature of long-lived mutants and a key mechanism of longevity assurance (McElwee et al., 2004; Shore et al., 2012; Steinbaugh et al., 2012).
We wished to determine whether the tissue morphogenesis defects observed in Celsr1 and Vangl2 mutant lungs could reflect a defect in the response of mutant endoderm to a key signal for branching.
