Sentence examples for mutating the corresponding from inspiring English sources

Additionally, a Q672K mutation produced a dramatic slowing of activation kinetics, a phenomenon also observed when mutating the corresponding residue in mammalian TMEM16F (Yang et al., 2012).

This finding concurs with a 72-fold reduction in activity seen upon mutating the corresponding Asn-226 to a Lysine in MnmE [23].

Mutating Gln194 in EGFR and Her3 may thus hinder their heterodimerization with Her2, and mutating the corresponding residue (Gln189) in dEGFR may hinder its homodimerization.

These data are in good agreement with the effects of mutating the corresponding conserved residues in TRPM7 and with deductions made from the crystal structures of the catalytic domains of other α-kinases, i.e. ChaK1/TRPM7 and MHCKA [ 12, 13].

Rather than making a drastic change to CR10 by mutating the corresponding lysine residue to tryptophan (see Figure 1), we created a variant of CR8 in which the central 'x' was mutated from aspartate to alanine.

(3) In M. petroleiphilum that does not encode the traditional methanol dehydrogenase (MxaFI), an alternative methanol dehydrogenase (Mdh2) has been identified, and mutating the corresponding gene lead to a methanol-negative phenotype and the loss of methanol dehydrogenase activity [ 91].

To retain the structure of the miRNA stem-loop precursor, we simultaneously mutated the corresponding 2-nt on miR* strand, the complementary strand of the mature miRNA (Fig. S1).

These findings are in agreement with those of Fernandes et al., who mutated the corresponding Trp residue in the Synechocystis enzyme to Phe, Leu, Val, and Ala in an attempt to broaden the substrate specificity; all but the Phe variant were found to be particularly impaired.

This would suggest that the modifications remaining in H. volcanii tRNA are also critical for functions that cannot be replaced by salt and we are currently mutating all the corresponding genes to address the functional of these modifications in vivo.

In contrast, mutating the active site Cys (corresponding to Cys at the active site in human Capn3) to a serine Capn3b-C120SS) abolished the ability of the mutant Capn3 to downregulate the p53 level induced by the injection of capn3b-MO.

We nevertheless attempted to complement a pfa4Δ strain using Swf1 constructs bearing the single point mutations, the triple mutant and a construct with two additional SDPs mutated to the corresponding residues in Pfa4, and neither complemented (not shown).