Sentence examples for mutating the equivalent from inspiring English sources

In this regard SUB appears to differ from BRI1, where mutating the equivalent two cysteines resulted in a functional protein [63], but behaves similarly to Cf-9, where equivalent mutations caused absence of Cf-9 activity [47].

In contrast to these observations, mutating the equivalent sequences in the MC4R poly(A) site had the opposite effects.

Mutating the equivalent residue in Lam4S2 (G1119R) completely inhibited sterol binding in vitro, showing that this residue is indeed critical.

Mutating the equivalent methionine to smaller residues in EAAT3 also resulted in less steep dependence of the ionic currents on Na+ concentration (Rosental and Kanner, 2010).

Using quantitative actin-binding assays, we show that mutating the equivalent residue abolishes F-actin binding in Coronin 1A, but not Coronin 1C.

Similar mean ΔΔG energy values were obtained upon mutating the equivalent Tyrosine residues in each of the three templates used for modelling RIN3-VPS9, corroborathis this result (Supplementary Material, Table S3).

We therefore mutated the equivalent residue in GluN2A, K80, and its possible interacting partner, to cysteine.

It has previously been shown that a large hydrophobic residue in the headgroup is essential for the N N interaction in several species (Kitagawa et al., 2011; van Breugel et al., 2011), so we mutated the equivalent residue, F143, to Asp.

Interestingly, we have also found that mutating the highly conserved equivalent residues in WNK1 ablates interaction with KLHL3.

Briefly, if one part of capsaicin specifically interacts with a residue on the channel, breaking this specific interaction by altering this part of capsaicin or by mutating the interacting residue should have equivalent effects (non-additive).

In this work, the two cofactor-binding loops (residues 185 192 and 382 392) were progressively mutated towards the equivalent sequence from the thermostable Thermus thermophilus TK and variants assessed for their impact on both thermostability and activity.