Sentence examples for mutated in many from inspiring English sources

While p53 is mutated in many types of tumours, mutations were found only in a limited number of MM (Greenblat et al, 1994).

These results confirm the somatic mutation landscape, where few genes are mutated in many tumors (for example, TP53) whereas many genes are recurrently mutated in few tumors.

Combined analysis of the mutated genes revealed set of genes that are mutated in many tumour types (201 genes are mutated in four or more different tumour types), and contribute to core cellular pathways and processes that are common to many tumour types.

The gene encoding the p110α catalytic subunit is mutated in many human cancers with the frequency of mutation reaching 30% in colon and breast cancer (Samuels et al, 2004; Vogt et al, 2007; Zhao and Vogt, 2008).

TP53 is mutated in many sporadic BCCs and a large majority of reported mutations are UVB type (Brash et al, 1991; Giglia-Mari and Sarasin, 2003; Reifenberger et al, 2005).

APC is also commonly mutated in many tumour types including colon and gastric, with the majority of mutations occurring in the mutation cluster region (Miyoshi et al, 1992; Ogasawara et al, 2006).

The first tumor suppressor gene to be identified was p53, which prevents neoplastic development by inhibiting the proliferation of abnormal cells and is one of the most commonly mutated genes in many human cancers.

FGFR1 mutated in as many as 10% of all KS cases and patients harboring FGFR1 mutations exhibited a broad spectrum of associated nonreproductive phenotypes, including CLP and dental agenesis [ 14].

Genome stability genes, such as TP53, ATM, BRCA1, BRCA2, and MSH2, are frequently mutated in tumors and many current antitumor therapeutics exploit genome stability defects through the use of DNA-damaging genotoxic agents (Helleday et al. 2008).

p53 remains the most commonly mutated gene in many common human cancers, with mutations (principally, but not exclusively, missense) estimated to occur in 50% of all cancers.

KRAS is a frequently mutated Oncogene in many types of cancer.