Sentence examples for mutated in several from inspiring English sources

RB1 (the gene coding for the retinoblastoma protein) has been found mutated in several types of cancer [ 2– 5], and germline mutations in the RB1 gene lead to retinoblastomas, in general diagnosed within the first year of life [ 6].

A second example of a well-described tumor-associated mutation is the epidermal growth factor receptor (EGFR), which is mutated in several types of cancers, including non-small cell lung cancer (NSCLC).

The gene family plexins, members of which are mutated in several monogenic neurodevelopmental disorders, was significantly enriched for associations with high IQ.

Notably, the Mcc tumor suppressor gene was found to be mutated in several colorectal tumors [145].

BRAF operates downstream of the RAS proteins and has been shown to be mutated in several tumor types [22].

Lamin A (LMNA) is a component of the nuclear lamina and is mutated in several human diseases, including Emery-Dreifuss muscular dystrophy (EDMD; OMIM ID# 181350) and the premature aging syndrome Hutchinson-Gilford progeria syndrome (HGPS; OMIM ID# 176670).

Although modern sequencing methods have revealed many of the genes that mutate in several different kinds of cancer, uncovering when each of these mutations occurs has been more difficult.

As already noticed (1, 6), most cancer genes, and in particular candidates, are specific for a given cancer type, and only few known cancer genes recurrently mutate in several cancers.

In addition to other traditional signaling pathways, which are frequently mutated in cancer, several recent studies reported that the components of the chromosome remodeling complex are frequently mutated in many cancer types including HCC.

Over 30 other peripheral membrane proteins and over 30 transmembrane proteins were also depleted, including several mutated in genetic disorders, indicating that AP-1 acts as a linchpin for intracellular CCV formation.

TP53 is the gene most often mutated in human cancer, and several studies have shown that loss of one allele in the germ line leads not only to a much increased risk of cancer but also to a decreased AR in lymphoid cells from both rodents (Clarke et al, 1993; Lowe et al, 1993) and humans (Camplejohn et al, 1995, 2000).