Sentence examples for mutated in multiple from inspiring English sources
10 Kandoth et al analyzed the Cancer Genome Atlas (TCGA) dataset and identified 127 "significantly mutated genes (SMGs)", defined as the genes mutated in multiple tumors in more than one type of cancer.
They called it MMAC1 (for mutated in multiple advanced cancers 1), and will publish a report in Nature Genetics.
Subsequently, RhoH has been found to be mutated in multiple myeloma and diffuse large B cell lymphomas (DLBCL [39], [40] and in AIDS-associated NHL[41], although the pathophysiological relevance of these findings are still unknown.
Fbxw7 is a tumour suppressor that is frequently mutated in multiple cancer types.
Importantly, lamins are mutated in multiple human diseases, known as laminopathies.
Finally, transformed cells are typically mutated in multiple members of a set of functionally related genes.
A predicted MYB binding site was identified in intron 1 of ZEB1, the site which is mutated in mice with multiple developmental malformations, some of which were suggested to be related to dysfunctional EMT or MET [ 20].
The tumor suppressor menin (MEN1) is mutated in the inherited disease multiple endocrine neoplasia type I, and has several documented cellular roles, including the activation and repression of transcription effected by several transcription factors.
Menin (MEN1) is the product of the tumor suppressor gene MEN1 that is mutated in the inherited syndrome multiple endocrine neoplasia type 1. MEN1 is predominately localized to the nucleus, and is reported to associate with several transcription factors to both repress (JunD, NF-kB) and stimulate (Smad3, ERα, VDR, PPARγ) gene activation [ 6].
The essentially random integration of retroviral DNA, and the fact that Int6 was mutated in virtually the same way in multiple independent tumors, suggests its potential role in malignant transformation.
The ability to mutate residues in multiple positions in a sequence is of particular interest as this can be used to address the question of combinatorial mutations simultaneously.
