Sentence examples for mutated in specific from inspiring English sources

Thus, identification of causative genes mutated in specific disorders and the study of relevant animal models are imperative.

Nevertheless, these results can be used for devising experimental studies of gain-of-function by tumor suppressors mutated in specific sites (hotspots) and/or specific tumor types with particularly strong evidence of positive selection.

Smaller kernels sizes may, conversely, reveal separate CISs that affect the same gene, which may be preferentially mutated in specific genetic backgrounds or result in expression of different mutant proteins (see below).

43 Thus, APC, VHL, PBRM1, GATA3, and other genes mutated in specific cancer types may qualify as the "gate keepers" of specific tissue type, the loss of which leads to the expansion of aberrant cell population and tumorigenesis.

The critical protein targets identified by the integrated approach were also shown to have clinically relevant mutation frequencies in patients with various cancer subtypes, including not only well-established pan-cancer genes, such as PTEN tumor suppressor, but also a number of targets that are less frequently mutated in specific cancer types, including ABL1 oncoprotein in acute myeloid leukemia.

In addition to pan-cancer recurrent genes, such as PTEN, which are mutated at high frequency in multiple cancers, this analysis also revealed a number of genes that are more uniquely mutated in specific cancer types; for instance, ABL1 in acute myeloid leukemia (AML) and HOXA1 in lung adenocarcinoma (Fig. 5B).

Nevertheless, the identification of a locus that is mutated in a specific disease, or of a base that is altered in an open reading frame, serves only as a starting point to uncover why a disease arises.

Several hypotheses have been proposed, including the evolutionary acceleration of genes involved in the control of fine motor control, such as the FOXP2 gene, which is also mutated in human-specific forms of language production impairment [20], [42].

However, this will need to be confirmed experimentally by comparing growth of wild type strains and strains mutated in CC-specific genes in apoplastic fluid of citrus species and of other plant species.

To study the role of p53 mutation in lung tumorigenesis, animal models in which the endogenous p53 gene is disrupted or mutated in a lung-specific manner, or in which mutant p53 transgenes are expressed in a lung-specific manner, would be of considerable value.

Interestingly, this junction region is highly conserved across species and the specific threonine mutated in rye is conserved in all α7 subunits.