Sentence examples for mutants to localize from inspiring English sources

Hence, the loss-of-function of both EndoAP143A, ΔLEN and the EndoA/F-BAR chimeras may be linked to an inability of these "curvature-challenged" mutants to localize properly to the sites of presynaptic endocytosis.

We next tested the ability of PatL1 mutants to localize to P-bodies.

Therefore, the inability of those mutants to localize to the centriole might further influence the ability of PLK4 to bind to STIL.

To test this model, we examined the ability of the Spn-F deletion mutants to localize to the tip of growing bristles in transgenic flies.

To define the structural elements responsible for localizing TIP150 to the MT plus ends in vivo, we assessed the ability of TIP150 deletion mutants to localize to the MT plus ends.

In either case, failure of the Pro mutants to localize to the cell surface suggests that the peculiar nature of proline, an imino acid, and not the hydrophobicity or bulkiness of the side chain is important for intracellular sorting.

In contrast, MMR protein complex formation was not detectable in the MSH2(R524P) cell line, which is consistent with the inability of this mutant to localize to the chromatin.

Similar to the yeast Myo1 mutants that no longer localize to actin patches, Myo1e-A159P and Myo1e-T119I mutants fail to localize to cell-cell junctions and intracellular vesicles (Bi et al., 2013; J.B. and M.K., unpublished observations), and exhibit a mostly cytosolic localization.

Whirlin has been shown to interact with myosin XVa via its third PDZ domain [5], [6] and myosin XVA mutants fail to localize whirlin at the stereocilia tip [5].

Instead, our TEN-domain mutants fail to localize to telomeres despite OE, and remain sequestered in Cajal bodies.

Furthermore, the TEN-domain mutants fail to localize to telomeres and cannot maintain telomere length in vivo.