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Exact(4)

Our results show that the region deleted in BDB mutants is required for efficient ROR2 phosphorylation.

Further work using ahk5 plants crossed with atrboh mutants is required to confirm how AHK5 and RBOH signalling interact.

One alternative to this hypothesis is that contractile activity itself, absent in paralyzed unc45b mutants, is required for timely Z-disc maturation.

Finally, to address the issue of whether the residual phosphatase activity associated with the LS SHP2 mutants is required for the GOF phenotype, we generated a double mutant in which the phosphatase activity of the Y279C mutant is eliminated by replacing the catalytic Cys459 with Ser and examined its effect on Gab1 binding and ERK1/2 activation upon either EGF or HGF stimulation.

Similar(56)

Further NMR binding kinetics study and enzymatic assays of the mutants are required to confirm our conclusion based on crystal structures.

Nonetheless, examination of endomembrane compartments by transmission electron microscopy is required to address this question and help determine whether bet11/bet12 mutants are required for maintenance of proper structure of the Golgi or TGN in pollen tubes.

Further characterizations of these escape mutants are required to elucidate the mechanism responsible for this phenomena.

However, further experiments involving gain-of-function or loss-of-function mutants are required to address this hypothesis.

However, previous studies have shown that both Y1065F and Y100F mutants are required for a cell spreading defect.

We show that cancer-associated p53 missense mutants are required for the survival of breast cancer cells.

Further careful analyses employing various hrs1 phosphorylation mutants are required to identify the precise phosphorylation timings and their roles throughout meiotic progression.

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