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The mutants having a higher level of tolerance than the WT were identified.
TSC mutant cell lines were highly sensitive to inhibition by AZD2014 with all mutants having a GI50 of <1 µM and 8/10 TSC1 mutants having a GI50 <200 nM (AstraZeneca, internal data).
FBS stimulated growth of both wildtype and NF1 mutant cells, with mutants having a growth advantage in all axenic conditions.
Up-regulated or unchanged metabolic rate, respectively, have been initially described in long-lived eat mutants (having a feeding defect) and calorie restricted worms [ 31].
Consistent with fln1 mutants having a more severe morphological phenotype, cells of fln1-1 wextremelymely vacuolated and contained chloroplasts with more extreme defects than those of fln2 cells.
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While some mutants had a monstrous appearance, many of them — including Havok — looked like supermodels.
The egy1 deletion mutants have a yellow-green phenotype and reduced granal thylakoids.
Swine receiving the rΔ727 813 mutants had a significant decrease in lymph node enlargement compared to rVR-2332.
The z3 2 and z3 3 mutants have a T-DNA insertion in the first exon, but in different locations.
From this, we determined that mtd1 1 mutants have a defect in gene-transfer through the male gametophyte (Table 2).
In Arabidopsis, although both single mutants of pksa/lap6 and pksb/lap5 were fertile, their double mutants had a male sterile phenotype (Dobritsa et al. 2010; Kim et al. 2010).
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