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Given that Fatp4-deficient mice and acs-20 mutant worms have surprisingly similar defects in the skin and cuticle barrier, respectively, the defects are likely to be caused by common mechanisms between mammals and worms.
nduf-7 (et19 ) mutant worms have a reduced respiration rate and longer lifespan, and are resistant to two different types of statins.
Consistent with this, several studies have shown that long-lived clk-1, isp-1, and nuo-6 mutant worms have increased ROS levels [ 16, 31, 50].
The mutant worms have a starved appearance, a smaller brood size, and a prolonged egg-laying period (Shibata et al., 2000).
The eat-2 mutants represent a well-studied genetic model of DR. Due to a mutation in a nonalpha nicotinic acetylcholine receptor subunit, the eat-2 mutant worms have defective pharyngeal pumping and ingest fewer bacteria (Lakowski & Hekimi, 1998).
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Unexposed mutant worms had on average only 1.5 extra cells, indicating that naphthalene exacerbates the problem.
These mutant worms had fewer and smaller P granules than normal worms.
Studying expression profiles in different mutant worms has enabled us to provide initial evidence of linked HIF-1 and Ins/IGF-1 signaling for globin regulation under severe hypoxic conditions in the nematode.
Strikingly, smc-5 ; brc-1 and smc-5 ; brd-1 double-mutant worms had decreased RAD-51 foci formation compared to smc-5 mutant worms in the absence and the presence of UV treatment.
How might you interpret the fact that dpl-1 slr-2 mutant worms also have an L1 arrest phenotype?
The latter is further supported by the inability of metformin to extend the lifespan of sams-1 mutant worms, which have a 65% decrease in SAMe levels (Walker et al., 2011).
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